With a number of injuries to both sides, debuts are handed out by both coaches and Mike Tindall has been handed the England captaincy.
Tindall will hope to keep his teammates calm in what could be an electric atmosphere at the Millennium Stadium which will surely spur the Welsh on, the home side are currently 13/8 outsiders with bet365.
England looked to have turned into a real force after running New Zealand close and beating Australia comfortably but a stuttering performance against Fiji and a home loss to South Africa have put them back in their place.
Wales did not win any of their 4 Autumn Internationals but pushed the big 3 very very close each time and will do the same to England; Betdaq offer evens about a Wales win with a 4 point headstart.
The bookies are wise to the Welsh efforts then but perhaps 4/6 about the Welsh with a 6 point start is worth taking (Ladbrokes). Wales can come out at real pace in front af a patisan crowd and go into the break with the lead, a 5/4 chance with Paddy Power.
Friday 4 February
Wales v England (19:45)