Manchester United began their season with a 3-1 win at Bournemouth and they are strong favourites at 1/2 (Paddy Power) to beat Southampton on Friday night.
Jose Mourinho might field the same XI and you can get 9/2 (William Hill) that Zlatan Ibrahimovic opens the scoring after finding the net at the Vitality Stadium.
The Saints created enough chances to beat Watford last weekend and Claude Puel’s side are 17/2 (BetVictor) to win at Old Trafford, although it appears that Jose Fonte will be making the switch to the Red Devils.
However, Nathan Redmond found the net against the Hornets and he’s 9/1 (Stan James) to break the deadlock.
Back United to win to nil at 11/8 with Betvictor
Compare odds and bet on over 100 markets on every game